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Azelaic acid is an organic compound with a saturated dicarboxylic acid which is found in wheat, barley and rye. It is also known as nonanedioic acid. It can be obtained by the ozonolysis of oleic acid at an industry level and naturally, it can be produced by a yeast that is found on the skin called Malassezia furfur. The property value of hydrogen bond acceptor and hydrogen bond donor are 2 and 4 respectively. The rotatable bond count is 8.
Following is the table of formulas of azelaic acid:
| Molecular formula | C9H16O4 |
| The Simplified molecular-input line-entry system (SMILES) | OC(=O)CCCCCCCC(O)=O |
Structure Of Azelaic Acid
Properties Of Azelaic Acid
| IUPAC name | Nonanedioic acid |
| Molecular formula | C9H16O4 |
| Molecular weight | 188.223 g/mol |
| Melting point | 109 to 111℃ |
| Boiling point | 286℃ |
| Density | 1.443 g/mL |
| Solubility in water | 2.14 g/L |
| Appearance | White solid |
| Refractive index | 1.4303 at 111℃ |
Applications Of Azelaic Acid
- It is used as a thickening agent in polymer industries.
- In the medical industry, it is used to cure mild to moderate acne and skin pigmentation.
- It is also used in the inhibition of microbial cellular protein synthesis.
Frequently Asked Questions – FAQs
What is the composition of azelaic acid?
Azelaic acid (AzA) is an organic compound with the formula HOOC(CH2)7COOH. This saturated dicarboxylic acid exists as a white powder.
What is azelaic acid used for?
Azelaic acid topical cream is used to treat mildly to moderately inflamed acne. The topical foam and gel are used to treat mild to moderate rosacea. For acne, it works by killing the bacteria that cause acne and by keeping the skin pores clean. This medicine is available only with your doctor’s prescription.
Is azelaic acid an AHA or BHA?
One of the buzziest skincare acids around is Azelaic acid. It’s different because it doesn’t fall into the AHA or BHA category. It’s produced by yeast that occurs on our skin naturally and is the answer to a whole load of skincare woes.
What is the formula for azelaic acid gel?
Preferably, the azelaic acid gel comprises the following components by weight percentage: 15% of azelaic acid, 2% of ZEN, 1% of salicylic acid, 70% of 1,3-propylene glycol and 12% of water. Preferably, the water is deionized water.
Is azelaic acid same as salicylic?
And this is what becomes the most determining factor for choosing between azelaic acid vs salicylic acid. While azelaic acid is gentler and is most suited for sensitive skin, salicylic acid has far more aggressive exfoliating properties than can cause irritation and issues if your skin type is very sensitive.
Is azelaic acid salicylic acid?
Topical azelaic acid reduces your body’s natural production of keratin cells; this prevents blockage of pores and sebaceous glands. The action of killing the acne-causing bacteria helps ward off acne. Salicylic acid works by deeply cleansing the pores and clearing out the debris that causes breakouts and blemishes.
What happens if I use azelaic acid everyday?
Can You Use Azelaic Acid Every Day? So you have scope to use Azelaic Acid up to twice a day and its fine to be used daily. In fact, like most great actives, its best results are achieved through daily use. If you have sensitive skin or a condition like rosacea or POD, start using it on alternate days initially.
What not to pair with azelaic acid?
AHAs: Most experts caution against using AHAs (alpha-hydroxy acids) with azelaic acid, since the combination can increase skin sensitivity and make skin red, irritated and scaly. BHAs: BHAs (beta-hydroxy acids), such as salicylic acid, can also increase sensitivity when combined with azelaic acid.
Can I use azelaic every night?
Yes, it’s safe to use azelaic acid every day. Some prescription-strength products are designed to be used two times per day.
What pairs well with azelaic acid?
It is wise to combine azelaic acid with a treatment containing an acid with exfoliating properties such as glycolic acid or lactic acid. Together, they will visibly refine your skin texture and fight against excess sebum and pore clogging.
Can I layer vitamin C and azelaic acid?
Can I use vitamin C and azelaic acid together? Yes, you can use vitamin C and azelaic acid products together – these ingredients complement one another. Using them together may speed up the results for evening skin tone and fading marks by targeting the issue via multiple pathways.
Is azelaic acid or niacinamide better?
If you have extremely dry skin, you may find that niacinamide is better than azelaic acid due to its ability to support the skin’s natural protective barrier (and thus, encourage moisture retention). But in general, these two ingredients make for a dynamic duo with a wide range of potential benefits to offer.
What is the best form of azelaic acid?
Below, we’ve compiled our experts’ favorite products containing azelaic acid, as well as highly rated options from brands we’ve previously covered.
- The Ordinary Azelaic Acid Serum.
- Paula’s Choice 10% Azelaic Acid Booster.
- Sesderma Azelac Ru Facial Serum.
- Tula Clear It Up Acne Clearing and Tone Correcting Gel.
Which is better retinol or azelaic acid?
Both assist with cellular turnover, but azelaic acid acts as an exfoliant and helps with bacteria and inflammation, while retinol boosts cell renewal. Both can cause skin irritation, but retinol has additional side effects like dry skin and photosensitivity (Mukherjee, 2006).
Is azelaic acid better than salicylic?
Azelaic acid’s gentle yet effective antimicrobial and brightening properties make it a go-to for those with sensitive or acne-prone skin, while salicylic acid’s pore-purifying and exfoliating prowess makes it an excellent choice for oily or acne-prone individuals.
Does azelaic acid clog pores?
One of the many abilities of azelaic acid is that it can prevent clogged pores. Acne begins with 2 main changes to the sebaceous (hair) follicles on the skin. The first is a process called follicular hyperkeratinization, which is an excessive shedding of skin cells into the hair follicles.
Why not to use azelaic acid?
Be extra careful with azelaic acid if you have dark skin, because it can cause changes in skin color. Talk to your doctor right away if your skin becomes lighter in some areas. Azelaic acid might make asthma worse. If you have asthma, talk to your doctor if you notice changes in your condition.
Can I use salicylic and azelaic together?
Combining these components can help to cleanse and brighten the skin, lessen inflammation, and enhance the general texture of the skin. In one study, it was discovered that using a 10% azelaic acid and a 2% salicylic acid combination for 12 weeks reduced acne lesions and enhanced skin texture.
Can I mix azelaic acid with niacinamide?
Yes, you can mix niacinamide and azelaic acid together—these ingredients enhance each other’s benefits (and one doesn’t deactivate the other). Do I use niacinamide before or after azelaic acid? For best results, use the Niacinamide Booster before the Azelaic Acid Booster.
Can I leave azelaic acid overnight?
Everything You Need to Know Before Using Azelaic Acid
Be patient – Azelaic acid may be effective, but it’s not a treatment that will work overnight.
Should I use moisturizer after azelaic acid?
Azelaic acid typically has a lighter, more gel-like consistency, while moisturizers are usually thicker. So, in the world of skincare, where it’s all about layering smart, azelaic acid should ideally strut onto your skin’s stage before the moisturizer makes its grand entrance.
Can I use azelaic acid 20% twice a day?
It’s safe to be used twice a day but if you have sensitive skin, always be cautious and build azelaic acid into your skin slowly by using it every other day. I often find anecdotally that patients are able to use their retinoid more easily once they’ve used azelaic acid for a while.
What to layer after azelaic acid?
Take note of the fact that you should always apply azelaic acid to a clean face. Afterward, you can add moisturizer and sunscreen.
Does azelaic acid make skin worse at first?
While rare, some individuals may experience a mild and temporary increase in acne or skin congestion when first using azelaic acid. This initial reaction is not technically considered skin purging but rather an adjustment period as your skin adapts to the new ingredient.
What percentage of azelaic acid is effective?
The results of the present study showed that topical administration of 20% AZA and 5% TA is efficient in the treatment of PIH in patients with acne vulgaris.
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